ITCH (phospho Tyr420) Antibody
| Code | Size | Price |
|---|
| PSI-79-885-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Immunohistochemistry (IHC)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
AIF4, AIP4, NAPP1
Background:
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain.
Background References:
- Chen X., Genomics 73:238-241(2001).
- Deloukas P., Nature 414:865-871(2001).
- Wood J.D., Mol. Cell. Neurosci. 11:149-160(1998).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ITCH (phospho Tyr420) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 420 (F-I-Y (p)-G-N) derived from Human ITCH .
Modifications:
Phospho-Specific
NCBI Gene ID #:
83737
NCBI Official Name:
itchy E3 ubiquitin protein ligase
NCBI Official Symbol:
ITCH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
102 kDa
Protein Accession #:
NP_001244066.1
Protein GI Number:
380420335
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of ITCH only when phosphorylated at tyrosine 420.
Swissprot #:
Q96J02