RSK1/2/3/4 (phospho Ser221/227/S218/232) Antibody
| Code | Size | Price |
|---|
| PSI-79-864-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20˚,C for up to one year.
Documents
Further Information
Additional Names:
KS6A1, KS6AA, MAPKAP-K1a, RSK1
Application Note:
Western Blot: 1:500~1:1000
Background:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway.
Background References:
- Moller D.E., Am. J. Physiol. 266:C351-C359(1994).
- Gregory S.G., Nature 441:315-321(2006).
- The MGC Project Team, Genome Res. 14:2121-2127(2004).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
RSK1/2/3/4 (phospho Ser221/227/S218/232) antibody was raised against a peptide sequence around phosphorylation site of Serine 221/227/218/232 (A-Y-S (p)-F-C) derived from Human RSK1/2/3/4.
Modifications:
Phospho-Specific
NCBI Gene ID #:
6195/6197/6196/27330
NCBI Official Name:
ribosomal protein S6 kinase, 90kDa, polypeptide 1, ribosomal protein S6 kinase, 90kDa, polypeptide 2, ribosomal protein S6 kinase, 90kDa, polypeptide 3, ribosomal protein S6 kinase, 90kDa, polypeptide 6
NCBI Official Symbol:
RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
85 kDa
Protein Accession #:
NP_002944.2
Protein GI Number:
55743134
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of RSK1/2/3/4 only when phosphorylated at serine 221/227/218/232.
Swissprot #:
Q15418/P51812/Q15349/Q9UK32