TIE2 (phospho Tyr992) Antibody
| Code | Size | Price |
|---|
| PSI-79-867-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
Angiopoietin-1 receptor,EC=2.7.10.1 Tunica interna endothelial cell kinase Tyrosine-protein kinase receptor TEK Tyrosine-protein kinase receptor TIE-2 hTIE2 p140 TEK CD202b TEK TIE2
Application Note:
Western Blot: 1:500~1:1000
Background:
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
Background References:
- Schooley K.A., Baum P.R. Oncogene 8:663-670(1993)
- Dunham I. Nature 429:369-374(2004)
- Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TIE2 (phospho Tyr992) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 992 (E-V-Y (p)-V-K) derived from Human TIE2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
7010
NCBI Official Name:
TEK tyrosine kinase, endothelial
NCBI Official Symbol:
TEK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
126 kDa
Protein Accession #:
NP_000450.2
Protein GI Number:
218511853
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The Antibody detects endogenous levels of TIE2 only when phosphorylated at Tyr992.
Swissprot #:
Q02763