Androgen Receptor (phospho Tyr363) Antibody
| Code | Size | Price |
|---|
| PSI-79-872-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
ANDR, Androgen receptor, Dihydrotestosterone receptor, NR3C4
Application Note:
Western Blot: 1:500~1:1000
Background:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Background References:
- Lubahn D.B., Mol. Endocrinol. 2:1265-1275(1988).
- Chang C., Proc. Natl. Acad. Sci. U.S.A. 85:7211-7215(1988).
- Tilley W.D., Proc. Natl. Acad. Sci. U.S.A. 86:327-331(1989).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Androgen Receptor (phospho Tyr363) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 363 (D-Y-Y (p)-N-F) derived from Human Androgen Receptor.
Modifications:
Phospho-Specific
NCBI Gene ID #:
367
NCBI Official Name:
androgen receptor
NCBI Official Symbol:
AR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
85 kDa
Protein Accession #:
NP_000035.2
Protein GI Number:
21322252
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of Androgen Receptor only when phosphorylated at tyrosine 363.
Swissprot #:
P10275