FGFR1/2 (phospho Tyr463/466) Antibody
| Code | Size | Price |
|---|
| PSI-79-883-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
BFGFR, CEK, FLG, CD331, FLT2
Background:
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
Background References:
- Itoh N., Biochem. Biophys. Res. Commun. 169:680-685(1990).
- Dionne C.A., EMBO J. 9:2685-2692(1990).
- Johnson D.E., Mol. Cell. Biol. 10:4728-4736(1990).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FGFR1/2 (phospho Tyr463/466) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 463/466 (S-E-Y (p)-E-L) derived from Human FGFR1/2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
2260/2263
NCBI Official Name:
fibroblast growth factor receptor 1, fibroblast growth factor receptor 2
NCBI Official Symbol:
FGFR1, FGFR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
91 kDa
Protein Accession #:
NP_075598.2
Protein GI Number:
291327489
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of FGFR1/2 only when phosphorylated at tyrosine 463/466.
Swissprot #:
P11362/P21802