PAK5/6 (phospho Ser602/Ser560) Antibody
| Code | Size | Price |
|---|
| PSI-79-921-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
PAK5, PAK 6, kinase PAK6
Application Note:
Western Blot: 1:500~1:1000
Background:
This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development.
Background References:
- Yang F., J. Biol. Chem. 276:15345-15353(2001).
- Wagner T., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
- Sjoeblom T., Science 314:268-274(2006).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PAK5/6 (phospho Ser602/Ser560) antibody was raised against a peptide sequence around phosphorylation site of Serine 602/560 (R-K-S (p)-L-V) derived from Human PAK5/6.
Modifications:
Phospho-Specific
NCBI Gene ID #:
57144/56924
NCBI Official Name:
p21 protein (Cdc42/Rac)-activated kinase 5, p21 protein (Cdc42/Rac)-activated kinase 6
NCBI Official Symbol:
PAK5, PAK6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
75 kDa
Protein Accession #:
NP_065074.1
Protein GI Number:
24308191
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of PAK5/6 only when phosphorylated at serine 602/560.
Swissprot #:
Q9P286/Q9NQU5