EPHA2/5 (phospho Tyr594) Antibody
| Code | Size | Price |
|---|
| PSI-79-942-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
ARCC2, ECK, EPHA2
Application Note:
Western Blot: 1:500~1:1000
Background:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway.
Background References:
- Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990).
- Gregory S.G., Nature 441:315-321(2006).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
EPHA2/5 (phospho Tyr594) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 594 (H-T-Y (p)-E-D) derived from Human EPHA2/5.
Modifications:
Phospho-Specific
NCBI Gene ID #:
1969/2044
NCBI Official Name:
EPH receptor A2, EPH receptor A5
NCBI Official Symbol:
EPHA2, EPHA5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
110 kDa
Protein Accession #:
NP_004422.2
Protein GI Number:
32967311
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The Antibody detects endogenous levels of EPHA2 only when phosphorylated at tyrosine 594.
Swissprot #:
P29317/P54756