EPHA4 (phospho Tyr596) Antibody
| Code | Size | Price |
|---|
| PSI-79-943-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
EK8, hEK8, EPH-like kinase 8
Application Note:
Western Blot: 1:500~1:1000
Background:
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity.
Background References:
- Rikova K., Cell 131:1190-1203(2007) [PubMed: 18083107].
- Richter M., J. Neurosci. 27:14205-14215(2007) [PubMed: 18094260].
- Fu W.Y., Nat. Neurosci. 10:67-76(2007) [PubMed: 17143272].
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
EPHA4 (phospho Tyr596) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 596 (R-T-Y (p)-V-D) derived from Human EPHA4 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
2043
NCBI Official Name:
EPH receptor A4
NCBI Official Symbol:
EPHA4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
110 kDa
Protein Accession #:
NP_004429.1
Protein GI Number:
1711371
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of EPHA4 only when phosphorylated at tyrosine 596
Swissprot #:
P54764