SirT1 (phospho Ser47) Antibody
| Code | Size | Price |
|---|
| PSI-79-978-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
hSIR2, hSIRT1, NAD-dependent deacetylase sirtuin 1, SIR1, SIR2L1
Application Note:
Western Blot: 1:500~1:1000
Background:
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively.
Background References:
- Gao Z, et al. (2011) J Biol Chem 286, 22227-34. Zschoernig B, Mahlknecht U (2009)Biochem Biophys Res Commun 381, 372-7. Nasrin N, et al. (2009)PLoS One 4, e8414.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SirT1 (phospho Ser47) antibody was raised against a peptide sequence around phosphorylation site of serine 47 (E-R-S (p)-P-G) derived from Human SirT1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
23411
NCBI Official Name:
sirtuin 1
NCBI Official Symbol:
SIRT1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
110 kDa
Protein Accession #:
NP_001135970.1
Protein GI Number:
7657575
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of SirT1 only when phosphorylated at serine 47.
Swissprot #:
Q96EB6