MSK1 (phospho Ser212) Antibody
| Code | Size | Price |
|---|
| PSI-79-984-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
polypeptide 5, KS6A5, MSPK1, RPS6KA5, RLPK
Application Note:
Western Blot: 1:500~1:1000
Background:
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
Background References:
- McCoy CE, et al. (2007) Biochem J 402, 491-501
- McCoy CE, et al. (2005)Biochem J 387, 507-17
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MSK1 (phospho Ser212) antibody was raised against a peptide sequence around phosphorylation site of serine 212 (A-Y-S (p)-F-C) derived from Human MSK1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
9252
NCBI Official Name:
ribosomal protein S6 kinase, 90kDa, polypeptide 5
NCBI Official Symbol:
RPS6KA5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
90 kDa
Protein Accession #:
NP_004746.2
Protein GI Number:
32528295
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of MSK1 only when phosphorylated at serine 212.
Swissprot #:
O75582