VE-Cadherin (phospho Tyr731) Antibody

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ProSci
Product Code: PSI-80-000
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-80-000-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from HepG2 cells treated with Na3VO4 using Phospho-VE-Cadherin (Tyr731) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from HepG2 cells treated with Na3VO4 using Phospho-VE-Cadherin (Tyr731) Antibody. The lane on the right is treated with the antigen-specific peptide.

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Further Information

Additional Names:
Vascular endothelial cadherin, VE-cadherin, 7B4 antigen, CDH5, CD144 antigen
Application Note:
Western Blot: 1:500~1:1000
Background:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen.
Background References:
  • Wessel F, et al. (2014) Nat Immunol 15, 223-30
  • Sawada J, et al. (2012) Cancer Cell 22, 235-49
  • Turowski P, et al. (2008) J Cell Sci 121, 29-37
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
VE-Cadherin (phospho Tyr731) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine731 (H-I-Y (p)-G-Y) derived from Human VE-Cadherin.
Modifications:
Phospho-Specific
NCBI Gene ID #:
1003
NCBI Official Name:
cadherin 5, type 2 (vascular endothelium)
NCBI Official Symbol:
CDH5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
130 kDa
Protein Accession #:
NP_001786.2
Protein GI Number:
166362713
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of VE-Cadherin only when phosphorylated at tyrosine 731.
Swissprot #:
P33151