ETK (phospho Tyr566) Antibody

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ProSci
Product Code: PSI-80-003
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-80-003-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from HeLa cells treated with Serum using Phospho-ETK (Tyr566) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from HeLa cells treated with Serum using Phospho-ETK (Tyr566) Antibody. The lane on the right is treated with the antigen-specific peptide.

Documents

Further Information

Additional Names:
BMX, BMX NON-receptor tyrosine kinase, Bone marrow kinase BMX, Epithelial and endothelial tyrosine kinase, NTK38
Application Note:
Western Blot: 1:500~1:1000
Background:
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility.
Background References:
  • Zhang R, et al. (2003) J Biol Chem 278, 51267-76
  • Tsai YT, et al. (2000) Mol Cell Biol 20, 2043-54
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ETK (phospho Tyr566) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine566 (D-Q-Y (p)-V-S) derived from Human ETK.
Modifications:
Phospho-Specific
NCBI Gene ID #:
660
NCBI Official Name:
BMX non-receptor tyrosine kinase
NCBI Official Symbol:
BMX
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
78 kDa
Protein Accession #:
NP_001712.1
Protein GI Number:
1705489
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of ETK only when phosphorylated at tyrosine 566.
Swissprot #:
P51813