HDAC6 (phospho Ser22) Antibody

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ProSci
Product Code: PSI-80-033
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-80-033-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from NIH-3T3 tissue using HDAC6 (Phospho-Ser22) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from NIH-3T3 tissue using HDAC6 (Phospho-Ser22) Antibody. The lane on the right is treated with the antigen-specific peptide.

Documents

Further Information

Additional Names:
HD6, HDA6, Histone deacetylase 6, JM21,
Application Note:
Western Blot: 1:500~1:1000
Background:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
Background References:
  • Chen S, Owens GC, Makarenkova H, Edelman DB (2010)PLoS One 5, e10848.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
HDAC6 (phospho Ser22) antibody was raised against a peptide sequence around phosphorylation site of serine 22 (P-Q-S (p)-P-P) derived from Human HDAC6.
Modifications:
Phospho-Specific
NCBI Gene ID #:
10013
NCBI Official Name:
histone deacetylase 6
NCBI Official Symbol:
HDAC6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
131 kDa
Protein Accession #:
NP_006035.2
Protein GI Number:
13128864
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of HDAC6 only when phosphorylated at serine 22.
Swissprot #:
Q9UBN7