IGF2R (phospho Ser2409) Antibody
| Code | Size | Price |
|---|
| PSI-79-826-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
CI-MPR, CI-MPR, MPR300, MPRI
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Background References:
- Morgan D.O., Nature 329:301-307(1987).
- Oshima A., J. Biol. Chem. 263:2553-2562(1988).
- Killian J.K., Mamm. Genome 10:74-77(1999)
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IGF2R (phospho Ser2409) antibody was raised against a peptide sequence around phosphorylation site of Serine 2409 (Q-D-S (p)-E-D) derived from Human IGF2R.
Modifications:
Phospho-Specific
NCBI Gene ID #:
3482
NCBI Official Name:
insulin-like growth factor 2 receptor
NCBI Official Symbol:
IGF2R
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
300 kDa
Protein Accession #:
NP_000867.2
Protein GI Number:
317373416
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of IGF2R only when phosphorylated at serine 2409.
Swissprot #:
P11717