Trophinin Antibody
| Code | Size | Price |
|---|
| PSI-8245-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-8245-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Trophinin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Documents
Further Information
Additional Names:
TRO, MAGE-d3, MAGED3
Application Note:
Trophinin antibody can be used for detection of Trophinin by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry at 10 μg/ml.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
Trophinin, also known as TRO or MAGED3, is an apical cell adhesion molecule that is implicated in the initial attachment during the process of embryo implantation and functions by mediating cell adhesion between trophoblastic and endometrial epithelial cells (1,2). Trophinin is a membrane protein expressed in chorionic villi trophoblasts and in maternal endometrial epithelial cells in an implantation-dependent manner and interacts with Bystin and Tastin, facilitating cell adhesion and embryo implantation (3,4). The induction of Trophinin expression may be a useful method for improving implantation rates and can be a potential diagnostic factor and biomarker for human cancer (4,5).
Background References:
- Fukuda MN, Sato T, Nakayama J, et al. Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. Genes Dev. 1995; 9:1199-210.
- Ma L, Yin M, Wu X, et al. Expression of trophinin and bystin identifies distinct cell types in the germinal zones of adult rat brain. Eur. J. Neurosci. 2006; 23:2265-76.
- Tamura N, Sugihara K, Akama TO, et al. Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelial cells through PKC-d. Cell Cycle 2011; 10:135-43.
- Chen KY, Lee YC, Lai JM, et al. Identification of trophinin as an enhancer for cell invasion and a prognostic factor for early stage lung cancer. Eur. J. Cancer. 2007; 43:782-90.
Buffer:
Trophinin antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Trophinin antibody was raised against a 16 amino acid peptide near the amino terminus of human Trophinin.
The immunogen is located within amino acids 390 - 440 of Trophinin.
The immunogen is located within amino acids 390 - 440 of Trophinin.
NCBI Gene ID #:
7216
NCBI Official Name:
trophinin
NCBI Official Symbol:
TRO
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 78, 157 kDa
Observed: 94 kDa
Observed: 94 kDa
Protein Accession #:
NP_001034794
Protein GI Number:
89276766
Purification:
Trophinin antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell,Cancer,Apoptosis
SPECIFICITY:
Trophinin antibody is human, mouse and rat reactive. Multiple isoforms of Trophinin are known to exist.
Swissprot #:
Q12816
User NOte:
Optimal dilutions for each application to be determined by the researcher.