Bax (phospho Thr167) Antibody
| Code | Size | Price |
|---|
| PSI-79-802-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunofluorescence (IF)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
BAXA, Apoptosis regulator BAX, membrane isoform alpha, Bcl2-associated X protein
Background:
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Background References:
- Francesca Andriani. J Natl Cancer Inst, Sep 2001; 93: 1314 - 1324.
- H Martinez-Valdez. J. Exp. Med., Mar 1996; 183: 971.
- Joslyn K. Brunelle. J. Biol. Chem., Feb 2004; 279: 4305 - 4312.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Bax (phospho Thr167) antibody was raised against a peptide sequence around phosphorylation site of threonine167 (P-G-T (p)-P-T) derived from Human Bax.
Modifications:
Phospho-Specific
NCBI Gene ID #:
581
NCBI Official Name:
BCL2-associated X protein
NCBI Official Symbol:
BAX
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
21 kDa
Protein Accession #:
NP_620116.1
Protein GI Number:
388166
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of Bax only when phosphorylated at threonine 167.
Swissprot #:
Q07812