TGF beta Receptor II (phospho Ser225/250) Antibody
| Code | Size | Price |
|---|
| PSI-79-819-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
TGF-betaR2, TGFR2, kinase TGF-beta-R2
Background:
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.
Background References:
- RC Tripathi, Invest. Ophthalmol. Vis. Sci., Jan 1993; 34: 260.
- N Chegini, Endocrinology, Jul 1994; 135: 439.
- GW Mulheron, Endocrinology, Dec 1992; 131: 2609
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TGF beta Receptor II (phospho Ser225/250) antibody was raised against a peptide sequence around phosphorylation site of Serine 225/250 (D-R-S (p)-D-I) derived from Human TGF beta Receptor II.
Modifications:
Phospho-Specific
NCBI Gene ID #:
7048
NCBI Official Name:
transforming growth factor, beta receptor II (70/80kDa)
NCBI Official Symbol:
TGFBR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
64 kDa
Protein Accession #:
NP_003233.4
Protein GI Number:
67782324
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of TGF beta Receptor II only when phosphorylated at serine 225/250.
Swissprot #:
P37173