ILK (phospho Ser246) Antibody
| Code | Size | Price |
|---|
| PSI-79-847-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
ILK1, p59ILK, kinase ILK
Background:
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Background References:
- Hannigan G.E., Nature 379:91-96(1996).
- Janji B., Oncogene 19:3069-3077(2000).
- Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ILK (phospho Ser246) antibody was raised against a peptide sequence around phosphorylation site of Serine 246 (I-F-S (p)-H-P) derived from Human ILK.
Modifications:
Phospho-Specific
NCBI Gene ID #:
3611
NCBI Official Name:
integrin-linked kinase
NCBI Official Symbol:
ILK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
51 kDa
Protein Accession #:
NP_001014794.1
Protein GI Number:
4758606
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of ILK only when phosphorylated at serine 246.
Swissprot #:
Q13418