NMDAR1 (phospho Ser890) Antibody
| Code | Size | Price |
|---|
| PSI-79-798-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
GLURZ1, GRIN1, NMD-R1, NMDZ1, NMZ1
Background:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.
Background References:
- Guang Bai, J. Biol. Chem., Jan 1998; 273: 1086.
- Guang Bai, J. Biol. Chem., Mar 1995; 270: 7737.
- Mai T. Dang, PNAS, Oct 2006; 103: 15254 - 15259.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NMDAR1 (phospho Ser890) antibody was raised against a peptide sequence around phosphorylation site of Serine 890 (A-S-S (p)-F-K) derived from Human NMDAR1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
2902
NCBI Official Name:
glutamate receptor, ionotropic, N-methyl D-aspartate 1
NCBI Official Symbol:
GRIN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
120 kDa
Protein Accession #:
NP_015566.1
Protein GI Number:
11496971
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine 890.
Swissprot #:
Q05586