Tau (phospho Thr534/217) Antibody
| Code | Size | Price |
|---|
| PSI-79-838-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
MAPT, MTBT1, PHF-tau
Application Note:
Western Blot: 1:500~1:1000
Background:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Background References:
- Goedert M., Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988).
- Goedert M., EMBO J. 8:393-399(1989).
- Lee G., Neuron 2:1615-1624(1989).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Tau (phospho Thr534/217) antibody was raised against a peptide sequence around phosphorylation site of threonine 534/217 (L-P-T (p)-P-P) derived from Human Tau.
Modifications:
Phospho-Specific
NCBI Gene ID #:
4137
NCBI Official Name:
microtubule-associated protein tau
NCBI Official Symbol:
TAU
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
65 kDa
Protein Accession #:
NP_058519.3
Protein GI Number:
294862261
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of Tau only when phosphorylated at threonione 534/217.
Swissprot #:
P10636