HP1γ (phospho Ser93) Antibody

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ProSci
Product Code: PSI-79-879
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-879-0.1mg0.1mg£488.00
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from K562 cells treated with forskolin using HP1γ (Phospho-Ser93) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from K562 cells treated with forskolin using HP1γ (Phospho-Ser93) Antibody. The lane on the right is treated with the antigen-specific peptide.

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Further Information

Additional Names:
HECH, HP1 gamma, HP1Hs-gamma, chromobox 3
Application Note:
Western Blot: 1:500~1:1000
Background:
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Background References:
  • Ye Q., J. Biol. Chem. 271:14653-14656(1996).
  • Ye Q., Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
  • Koike N., FEBS Lett. 467:17-21(2000)
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
HP1γ (phospho Ser93) antibody was raised against a peptide sequence around phosphorylation site of Serine 93 (R-L-S (p)-L-S) derived from Human HP1γ .
Modifications:
Phospho-Specific
NCBI Gene ID #:
11335/653972
NCBI Official Name:
chromobox homolog 3
NCBI Official Symbol:
CBX3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
Protein Accession #:
NP_009207.2
Protein GI Number:
15082258
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of HP1? only when phosphorylated at serine 93.
Swissprot #:
Q13185