GRB2 (phospho Ser159) Antibody
| Code | Size | Price |
|---|
| PSI-79-882-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
GABJ, KIAA0571, pp100
Application Note:
Western Blot: 1:500~1:1000
Background:
This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Background References:
- Nishida K., Blood 93:1809-1816(1999).
- Nagase T., DNA Res. 5:31-39(1998).
- Taylor T.D., Nature 440:497-500(2006).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
GRB2 (phospho Ser159) antibody was raised against a peptide sequence around phosphorylation site of Serine 159 (K-S-S (p)-A-P) derived from Human GRB2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
9846
NCBI Official Name:
GRB2-associated binding protein 2
NCBI Official Symbol:
GAB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
100 kDa
Protein Accession #:
NP_536739.1
Protein GI Number:
18105042
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of GRB2 only when phosphorylated at serine 159.
Swissprot #:
Q9UQC2