C/EBP-alpha (phospho Thr230) Antibody
| Code | Size | Price |
|---|
| PSI-79-898-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
CCAAT/enhancer-binding protein alpha C/EBP alpha CEBPA
Application Note:
Western Blot: 1:500~1:1000
Background:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
Background References:
- Xanthopoulos K.G. Biochem. Biophys. Res. Commun. 215:106-113(1995)
- Schalwijk J. Biol. Chem. Hoppe-Seyler 378:373-379(1997)
- SeattleSNPs variation discovery resource Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
C/EBP-alpha (phospho Thr230) antibody was raised against a peptide sequence around phosphorylation site of threonine 230 (P-P-T (p)-P-V) derived from Human C/EBP-alpha.
Modifications:
Phospho-Specific
NCBI Gene ID #:
1050
NCBI Official Name:
CCAAT/enhancer binding protein (C/EBP), alpha
NCBI Official Symbol:
CEBPA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
NP_004355.2
Protein GI Number:
28872794
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The Antibody detects endogenous levels of C/EBP-alpha only when phosphorylated at Thr230.
Swissprot #:
P49715