HCK (phospho Tyr521) Antibody
| Code | Size | Price |
|---|
| PSI-79-931-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
p59-HCK/p60-HCK, Hemopoietic cell kinas, Tyrosine-protein kinase HCK
Application Note:
Western Blot: 1:500~1:1000
Background:
The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.
Background References:
- Quintrell N., Mol. Cell. Biol. 7:2267-2275(1987) [PubMed: 3496523].
- Ziegler S.F.,Mol. Cell. Biol. 7:2276-2285(1987) [PubMed: 3453117].
- Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039].
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
HCK (phospho Tyr521) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 521 (E-S-Q (p)-Y-Q) derived from Human HCK .
Modifications:
Phospho-Specific
NCBI Gene ID #:
3055
NCBI Official Name:
HCK proto-oncogene, Src family tyrosine kinase
NCBI Official Symbol:
HCK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
NP_002101.2
Protein GI Number:
287326139
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of HCK only when phosphorylated at tyrosine 521.
Swissprot #:
P08631