MAPK1/3 (phospho Tyr205/222) Antibody
| Code | Size | Price |
|---|
| PSI-79-934-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
ERK, ERT1, MAPK 1, MAPK2, ERK2
Application Note:
Western Blot: 1:500~1:1000
Background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Background References:
- Owaki H., Biochem. Biophys. Res. Commun. 182:1416-1422(1992).
- Dunham I., Nature 402:489-495(1999).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MAPK1/3 (phospho Tyr205/222) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 205/222 (K-G-Y (p)-T-K) derived from Human MAPK1/3 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
5594/5595
NCBI Official Name:
mitogen-activated protein kinase 1, mitogen-activated protein kinase 3
NCBI Official Symbol:
MAPK1, MAPK3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
NP_002736.3
Protein GI Number:
66932916
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of MAPK1/3 only when phosphorylated at tyrosine 205/222.
Swissprot #:
P28482/P27361