TPH2 (phospho Ser19) Antibody
| Code | Size | Price |
|---|
| PSI-79-937-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
ADHD7, NTPH, TPH2
Application Note:
Western Blot: 1:500~1:1000
Background:
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
Background References:
- Walther D.J., Science 299:76-76(2003).
- Scherer S.E., Nature 440:346-351(2006).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TPH2 (phospho Ser19) antibody was raised against a peptide sequence around phosphorylation site of Serine 19 (G-F-S (p)-L-D) derived from Human TPH2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
121278
NCBI Official Name:
tryptophan hydroxylase 2
NCBI Official Symbol:
TPH2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
56 kDa
Protein Accession #:
NP_775489.2
Protein GI Number:
31795563
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of TPH2 only when phosphorylated at serine 19.
Swissprot #:
Q8IWU9