MuSK (phospho Tyr755) Antibody
| Code | Size | Price |
|---|
| PSI-79-946-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
MUSK, Muscle, skeletal
Application Note:
Western Blot: 1:500~1:1000
Background:
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.
Background References:
- Valenzuela D.M., Neuron 15:573-584(1995).
- Humphray S.J., Nature 429:369-374(2004).
- Bergamin E., Mol. Cell 39:100-109(2010).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MuSK (phospho Tyr755) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 755 (A-D-Y (p)-Y-K) derived from Human MuSK .
Modifications:
Phospho-Specific
NCBI Gene ID #:
4593
NCBI Official Name:
muscle, skeletal, receptor tyrosine kinase
NCBI Official Symbol:
MUSK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
97 kDa
Protein Accession #:
NP_005583.1
Protein GI Number:
5031927
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of MuSK only when phosphorylated at tyrosine 755.
Swissprot #:
O15146