BRCA2 (phospho Ser3291) Antibody
| Code | Size | Price |
|---|
| PSI-79-949-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
BRCC2, BRCA2, subunit 2, BRCA1/BRCA2-containing complex
Application Note:
Western Blot: 1:500~1:1000
Background:
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.
Background References:
- Wooster R., Nature 378:789-792(1995).
- Tavtigian S.V., Nat. Genet. 12:333-337(1996).
- Dunham A., Nature 428:522-528(2004).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
BRCA2 (phospho Ser3291) antibody was raised against a peptide sequence around phosphorylation site of Serine 3291 (F-V-S (p)-P-A) derived from Human BRCA2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
675
NCBI Official Name:
breast cancer 2, early onset
NCBI Official Symbol:
BRCA2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
>350 kDa
Protein Accession #:
NP_000050.2
Protein GI Number:
14424438
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of BRCA2 only when phosphorylated at serine 3291.
Swissprot #:
P51587