DRP1 (phospho Ser637) Antibody
| Code | Size | Price |
|---|
| PSI-79-951-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
DLP1, DNM1L, DRP1, DVLP, Dymple
Application Note:
Western Blot: 1:500~1:1000
Background:
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation.
Background References:
- Shin H.-W., J. Biochem. 122:525-530(1997).
- Hong Y.-R., Biochem. Biophys. Res. Commun. 249:697-703(1998).
- Imoto M., J. Cell Sci. 111:1341-1349(1998).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DRP1 (phospho Ser637) antibody was raised against a peptide sequence around phosphorylation site of Serine 637 (K-L-S (p)-A-R) derived from Human DRP1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
10059
NCBI Official Name:
dynamin 1-like
NCBI Official Symbol:
DNM1L
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
82 kDa
Protein Accession #:
NP_036192.2
Protein GI Number:
171460914
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of DRP1 only when phosphorylated at serine 637.
Swissprot #:
O00429