Abl (phospho Tyr204) Antibody
| Code | Size | Price |
|---|
| PSI-79-953-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
p150, c-ABL, EC 2.7.10.2
Application Note:
Western Blot: 1:500~1:1000
Background:
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins).
Background References:
- Meyn MA, et al. (2006) J Biol Chem 281, 30907-16
- Steen H, et al. (2003) Mol Cell Proteomics 2, 138-45
- Salomon AR, et al. (2003) Proc Natl Acad Sci U S A 100, 443-8
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Abl (phospho Tyr204) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 204 (K-L-Y (p)-V-S) derived from Human c-Abl.
Modifications:
Phospho-Specific
NCBI Gene ID #:
25
NCBI Official Name:
ABL proto-oncogene 1, non-receptor tyrosine kinase
NCBI Official Symbol:
ABL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
135 kDa
Protein Accession #:
NP_005148.2
Protein GI Number:
62362414
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of Abl only when phosphorylated at tyrosine 204.
Swissprot #:
P00519