Trk A (phospho Tyr680/681) Antibody

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ProSci
Product Code: PSI-79-956
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-956-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from Jurkat cells treated with starved using Phospho-Trk A (Tyr680/Tyr681) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from Jurkat cells treated with starved using Phospho-Trk A (Tyr680/Tyr681) Antibody. The lane on the right is treated with the antigen-specific peptide.

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Further Information

Additional Names:
High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth, TRK, Trk-A
Application Note:
Western Blot: 1:500~1:1000
Background:
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Background References:
  • Liu HY, et al. (2005) J Biol Chem 280, 19461-71
  • Wahab NA, Weston BS, Mason RM (2005) J Am Soc Nephrol 16, 340-51
  • Marsh HN, et al. (2003) J Cell Biol 163, 999-1010
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Trk A (phospho Tyr680/681) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 680/tyrosine 681 (T-D-Y (p)-Y (p)-R-V) derived from Human Trk A.
Modifications:
Phospho-Specific
NCBI Gene ID #:
4914
NCBI Official Name:
neurotrophic tyrosine kinase, receptor, type 1
NCBI Official Symbol:
NTRK1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
87 kDa
Protein Accession #:
NP_001007793.1
Protein GI Number:
56118210
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of Trk A only when phosphorylated at tyrosine 680/tyrosine 681.
Swissprot #:
P04629