Ezrin (phospho Tyr146) Antibody

ProSci
Product Code: PSI-79-961
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-961-0.1mg0.1mg£488.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from 293 cells treated with UV using Phospho-Ezrin (Tyr146) Antibody. The lane on the right is treated with the antigen-specific peptide.

Western blot analysis of extracts from 293 cells treated with UV using Phospho-Ezrin (Tyr146) Antibody. The lane on the right is treated with the antigen-specific peptide.

Further Information

Additional Names:
Cytovillin, EZRI, p81, VIL2, Villin 2
Application Note:
Western Blot: 1:500~1:1000
Background:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Background References:
  • Murchie R, et al. (2014)Proc Natl Acad Sci U S A 111, 693-8. Kawahara T, et al. (2013)PLoS One 8, e79654 . Wang Y, Lazo JS (2012)Oncogene 31, 818-27.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ezrin (phospho Tyr146) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 146 (S-G-Y (p)-L-S) derived from Human Ezrin.
Modifications:
Phospho-Specific
NCBI Gene ID #:
7430
NCBI Official Name:
ezrin
NCBI Official Symbol:
EZR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
69 kDa
Protein Accession #:
NP_001104547.1
Protein GI Number:
161702986
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of Ezrin only when phosphorylated at tyrosine 146.
Swissprot #:
P15311