PDGFRa (phospho Tyr849) Antibody
| Code | Size | Price |
|---|
| PSI-79-964-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
CD140a, PDGFR-alpha, PGFRA, kinase PDGFR-alpha,
Application Note:
Western Blot: 1:500~1:1000
Background:
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi.
Background References:
- Rikova K, et al. (2007) Cell 131, 1190-203
- Moritz A, et al. (2010) Sci Signal 3, ra64
- Guo A, et al. (2008) Proc Natl Acad Sci U S A 105, 692-7
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PDGFRa (phospho Tyr849) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine849 (S-N-Y (p)-V-S) derived from Human PDGFRa.
Modifications:
Phospho-Specific
NCBI Gene ID #:
5156
NCBI Official Name:
platelet-derived growth factor receptor, alpha polypeptide
NCBI Official Symbol:
PDGFRA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
Protein Accession #:
NP_006197.1
Protein GI Number:
129892
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of PDGFRa only when phosphorylated at tyrosine 849.
Swissprot #:
P16234