CDK5 (phospho Tyr15) Antibody

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ProSci
Product Code: PSI-79-970
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-970-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from COS7 cells treated with EGF using Phospho-CDK5 (Tyr15) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from COS7 cells treated with EGF using Phospho-CDK5 (Tyr15) Antibody. The lane on the right is treated with the antigen-specific peptide.

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Further Information

Additional Names:
CDK5, CRK6, Cell division protein kinase 5, Tau protein kinase II catalytic subunit, kinase Cdk5
Application Note:
Western Blot: 1:500~1:1000
Background:
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM.
Background References:
  • Miao Y, et al. (2012)PLoS One 7, e42318. Li P, et al. (2011)Cell 147, 815-26. Nohara A, et al. (2011)J Biol Chem 286, 33457-65.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CDK5 (phospho Tyr15) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine15 (G-T-Y (p)-G-T) derived from Human CDK5.
Modifications:
Phospho-Specific
NCBI Gene ID #:
1020
NCBI Official Name:
cyclin-dependent kinase 5
NCBI Official Symbol:
CDK5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
Protein Accession #:
NP_001157882.1
Protein GI Number:
4826675
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of CDK5 only when phosphorylated at tyrosine 15.
Swissprot #:
Q00535