FAK (phospho Ser843) Antibody

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ProSci
Product Code: PSI-79-972
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-972-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from HepG2 cells treated with PMA using Phospho-FAK (Ser843) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from HepG2 cells treated with PMA using Phospho-FAK (Ser843) Antibody. The lane on the right is treated with the antigen-specific peptide.

Documents

Further Information

Additional Names:
FADK 1, FAK1, Focal adhesion kinase 1, PTK2, pp125FAK
Application Note:
Western Blot: 1:500~1:1000
Background:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Background References:
  • Jiang X, Sinnett-Smith J, Rozengurt E (2007)Cell Signal 19, 1000-10 . Jacamo R, Jiang X, Lunn JA, Rozengurt E (2007)J Cell Physiol 210, 436-44. Le Boeuf F, Houle F, Sussman M, Huot J (2006)Mol Biol Cell 17, 3508-20 .
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FAK (phospho Ser843) antibody was raised against a peptide sequence around phosphorylation site of serine843 (R-G-S (p)-I-D) derived from Human FAK .
Modifications:
Phospho-Specific
NCBI Gene ID #:
5747
NCBI Official Name:
protein tyrosine kinase 2
NCBI Official Symbol:
PTK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
120 kDa
Protein Accession #:
NP_001186578.1
Protein GI Number:
313851044
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of FAK only when phosphorylated at serine 843.
Swissprot #:
Q05397