GR (phospho Ser226) Antibody
| Code | Size | Price |
|---|
| PSI-79-987-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
GCCR, GCR, GRL;, NR3C1,
Application Note:
Western Blot: 1:500~1:1000
Background:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.
Background References:
- Wehmeyer L, Du Toit A, Lang DM, Hapgood JP (2014) J Biol Chem 289, 10235-51
- Bouazza B, et al. (2014) Am J Respir Cell Mol Biol 50, 301-15
- Lee MS, et al. (2013) Behav Brain Res 236, 56-61
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
GR (phospho Ser226) antibody was raised against a peptide sequence around phosphorylation site of serine 226 (L-L-S (p)-P-L) derived from Human GR.
Modifications:
Phospho-Specific
NCBI Gene ID #:
2908
NCBI Official Name:
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NCBI Official Symbol:
NR3C1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
86 kDa
Protein Accession #:
NP_000167.1
Protein GI Number:
4504133
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of GR only when phosphorylated at serine 226.
Swissprot #:
P04150