PDGFR beta (phospho Tyr740) Antibody
| Code | Size | Price |
|---|
| PSI-79-991-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
CD140b, PDGF-R-beta, PDGFR, PGFRB, kinase PDGFR-beta
Application Note:
Western Blot: 1:500~1:1000
Background:
PDGF Receptor ? encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Background References:
- Mitchell D, et al. (2007) J Biol Chem 282, 15606-18Wu JH, et al. (2006) J Biol Chem 281, 37758-72 . Bae YS, et al. (2000)J Biol Chem 275, 10527-31.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PDGFR beta (phospho Tyr740) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 740 (G-G-Y (p)-M-D) derived from Human PDGFR beta.
Modifications:
Phospho-Specific
NCBI Gene ID #:
5159
NCBI Official Name:
platelet-derived growth factor receptor, beta polypeptide
NCBI Official Symbol:
PDGFRB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
170 kDa
Protein Accession #:
NP_002600.1
Protein GI Number:
129890
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of PDGFR beta only when phosphorylated at tyrosine 740.
Swissprot #:
P09619