BCL-2 (phospho Ser87) Antibody

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ProSci
Product Code: PSI-79-992
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-992-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from HeLa cells treated with Nocodazole using Phospho-BCL-2 (Ser87) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from HeLa cells treated with Nocodazole using Phospho-BCL-2 (Ser87) Antibody. The lane on the right is treated with the antigen-specific peptide.

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Further Information

Additional Names:
Apoptosis regulator Bcl-2, BCL2
Application Note:
Western Blot: 1:500~1:1000
Background:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Background References:
  • Nencioni L, et al. (2009)J Biol Chem 284, 16004-15. Pattingre S, et al. (2009)J Biol Chem 284, 2719-28. Wei Y, et al. (2008)Mol Cell 30, 678-88.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
BCL-2 (phospho Ser87) antibody was raised against a peptide sequence around phosphorylation site of serine 87 (A-L-S (p)-P-V) derived from Human BCL-2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
596
NCBI Official Name:
B-cell CLL/lymphoma 2
NCBI Official Symbol:
BCL2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
Protein Accession #:
NP_000624.2
Protein GI Number:
72198189
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of BCL-2 only when phosphorylated at serine 87.
Swissprot #:
P10415