FGFR1 (phospho Tyr766) Antibody
| Code | Size | Price |
|---|
| PSI-79-993-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
FGFBR, FGFR-1, FLG, FLT2, c-fgr
Application Note:
Western Blot: 1:500~1:1000
Background:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Background References:
- Cross MJ, et al. (2002) Mol Biol Cell 13, 2881-93. Foehr ED, Raffioni S, Murray-Rust J, Bradshaw RA (2001)J Biol Chem 276, 37529-36. Cross MJ, et al. (2000)J Cell Sci 113 ( Pt 4), 643-51 .
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FGFR1 (phospho Tyr766) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 766 (Q-E-Y (p)-L-D) derived from FGFR1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
2260
NCBI Official Name:
fibroblast growth factor receptor 1
NCBI Official Symbol:
FGFR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
Protein Accession #:
NP_001167534.1
Protein GI Number:
105990522
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of FGFR1 only when phosphorylated at tyrosine 766.
Swissprot #:
P11362