XIAP (phospho Ser87) Antibody

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ProSci
Product Code: PSI-80-006
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-80-006-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from HepG2 cells treated with Anisomycin using Phospho-XIAP (Ser87) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from HepG2 cells treated with Anisomycin using Phospho-XIAP (Ser87) Antibody. The lane on the right is treated with the antigen-specific peptide.

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Further Information

Additional Names:
API3, BIR4, BIRC4, IAP3, X-linked IAP
Application Note:
Western Blot: 1:500~1:1000
Background:
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state.
Background References:
  • Huang X, Wu Z, Mei Y, Wu M (2013)EMBO J 32, 2204-16. Bornhauser BC, et al. (2007) Blood 110, 2084-91.Dan HC, et al. (2004)J Biol Chem 279, 5405-12.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
XIAP (phospho Ser87) antibody was raised against a peptide sequence around phosphorylation site of serine87 (K-V-S (p)-P-N) derived from Human XIAP .
Modifications:
Phospho-Specific
NCBI Gene ID #:
331
NCBI Official Name:
X-linked inhibitor of apoptosis
NCBI Official Symbol:
XIAP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
NP_001158.2
Protein GI Number:
32528299
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of XIAP only when phosphorylated at serine 87.
Swissprot #:
P98170