PDCD4 (phospho Ser457) Antibody

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ProSci
Product Code: PSI-80-012
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-80-012-0.1mg0.1mg£488.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from 293 cells treated with Serum using Phospho-PDCD4 (Ser457) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from 293 cells treated with Serum using Phospho-PDCD4 (Ser457) Antibody. The lane on the right is treated with the antigen-specific peptide.

Documents

Further Information

Additional Names:
neoplastic transformation inhibitor
Application Note:
Western Blot: 1:500~1:1000
Background:
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA
Background References:
  • Kakade D, Islam N, Maeda N, Adegoke OA (2014) BMC Cell Biol 15, 2. Wippich F, et al. (2013)Cell 152, 791-805 . LaRonde-LeBlanc N, et al. (2007)Mol Cell Biol 27, 147-56.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PDCD4 (phospho Ser457) antibody was raised against a peptide sequence around phosphorylation site of serine 457 (F-V-S (p)-E-G) derived from Human PDCD4 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
27250
NCBI Official Name:
programmed cell death 4 (neoplastic transformation inhibitor)
NCBI Official Symbol:
PDCD4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
51 kDa
Protein Accession #:
NP_001186421.1
Protein GI Number:
21735598
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of PDCD4 only when phosphorylated at serine 457.
Swissprot #:
Q53EL6