Cyclin D1 (phospho Thr286) Antibody
| Code | Size | Price |
|---|
| PSI-80-017-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
BCL-1 , oncogene, CYL-1, PRAD1, PRAD1
Application Note:
Western Blot: 1:500~1:1000
Background:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
Background References:
- Liou YC, et al. (2002) Proc Natl Acad Sci U S A 99, 1335-40
- Tagliati F, et al. (2006) Endocrinology 147, 3530-8
- Zou Y, et al. (2004) J Biol Chem 279, 27790-8
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Cyclin D1 (phospho Thr286) antibody was raised against a peptide sequence around phosphorylation site of threonine 286 (A-C-T (p)-P-T) derived from Human Cyclin D1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
595
NCBI Official Name:
cyclin D1
NCBI Official Symbol:
CCND1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
Protein Accession #:
NP_444284.1
Protein GI Number:
116152
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of Cyclin D1 only when phosphorylated at threonine 286.
Swissprot #:
P24385