GTPase Activating Protein (phospho Ser387) Antibody

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ProSci
Product Code: PSI-80-032
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-80-032-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from COS7 tissue using GTPase Activating Protein Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from COS7 tissue using GTPase Activating Protein Antibody. The lane on the right is treated with the antigen-specific peptide.

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Further Information

Additional Names:
GTPase activating protein, GTPase activating protein ID-GAP, RAC GTPase- activating protein 1, RACGAP1, RAC GTPase-activating protein
Application Note:
Western Blot: 1:500~1:1000
Background:
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation.
Background References:
  • Doki N, et al. (2009)Cancer Sci 100, 1675-9. Minoshima Y, et al. (2003)Dev Cell 4, 549-60.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
GTPase Activating Protein (phospho Ser387) antibody was raised against a peptide sequence around phosphorylation site of serine 387 (R-I-S (p)-G-C) derived from Human GTPase Activating Protein.
Modifications:
Phospho-Specific
NCBI Gene ID #:
29127
NCBI Official Name:
Rac GTPase activating protein 1
NCBI Official Symbol:
RACGAP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
72 kDa
Protein Accession #:
NP_001119575.1
Protein GI Number:
21361397
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of GTPase Activating Protein only when phosphorylated at serine 387.
Swissprot #:
Q9H0H5