Cyclin D1 (phospho Ser90) Antibody

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ProSci
Product Code: PSI-80-035
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-80-035-0.1mg0.1mg£488.00
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from K562 tissue using Cyclin D1 (Phospho-Ser90) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from K562 tissue using Cyclin D1 (Phospho-Ser90) Antibody. The lane on the right is treated with the antigen-specific peptide.

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Further Information

Additional Names:
BCL1, CCND1, CYL-1, PRAD1, PRAD1 oncogene
Application Note:
Western Blot: 1:500~1:1000
Background:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
Background References:
  • Sewing A, M?ller R (1994) Oncogene 9, 2733-6
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Cyclin D1 (phospho Ser90) antibody was raised against a peptide sequence around phosphorylation site of serine 90 (F-L-S (p)-L-E) derived from Human Cyclin D1 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
595
NCBI Official Name:
cyclin D1
NCBI Official Symbol:
CCND1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
31 kDa
Protein Accession #:
NP_444284.1
Protein GI Number:
116152
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of Cyclin D1 only when phosphorylated at serine 90.
Swissprot #:
P24385