Epo-R (phospho Tyr368) Antibody

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ProSci
Product Code: PSI-80-044
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-80-044-0.1mg0.1mg£488.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from K562 tissue using Epo-R (Phospho-Tyr368) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from K562 tissue using Epo-R (Phospho-Tyr368) Antibody. The lane on the right is treated with the antigen-specific peptide.

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Further Information

Additional Names:
EPO R, EPO-R, epor
Application Note:
Western Blot: 1:500~1:1000
Background:
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
Background References:
  • Funakoshi-Tago M, et al. (2010) J Biol Chem 285, 5296-307
  • Sulahian R, Cleaver O, Huang LJ (2009) Blood 113, 5287-97
  • Zhang YL, et al. (2009) Mol Cell 33, 266-74
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Epo-R (phospho Tyr368) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine 368 (D-T-Y (p)-L-V) derived from Human Epo-R.
Modifications:
Phospho-Specific
NCBI Gene ID #:
2057
NCBI Official Name:
erythropoietin receptor
NCBI Official Symbol:
EPOR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Protein Accession #:
NP_000112.1
Protein GI Number:
4503591
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous level of Epo-R only when phosphorylated at tyrosine 368.
Swissprot #:
P19235