p90 RSK (phospho Thr573) Antibody
| Code | Size | Price |
|---|
| PSI-79-791-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
KS6A1, p90RSK1, RSK1, RPS6KA1
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.
Background References:
- Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206.
- Ye Zhang, J. Biol. Chem., May 2002; 277: 19042 - 19048.
- Ganesh R. Panta, Mol. Cell. Biol., Mar 2004; 24: 1823 - 1835.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
p90 RSK (phospho Thr573) antibody was raised against a peptide sequence around phosphorylation site of threonine 573 (L-M-T (p)-P-C) derived from Human p90 RSK.
Modifications:
Phospho-Specific
NCBI Gene ID #:
6195
NCBI Official Name:
ribosomal protein S6 kinase, 90kDa, polypeptide 1
NCBI Official Symbol:
RPS6KA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
95 kDa
Protein Accession #:
NP_002944.2
Protein GI Number:
292457
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of P90RSK only when phosphorylated at threonine 573.
Swissprot #:
Q15418