MER/SKY (phospho Tyr749/681) Antibody

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ProSci
Product Code: PSI-79-853
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-853-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from 3T3 cells treated with EGF using MER/SKY (Phospho-Tyr749/681) Antibody. The lane on the right is treated with the antigen-specific peptide.
2 / 2
Immunohistochemical analysis of paraffin-embedded human brain tissue using MER/SKY (Phospho-Tyr749/681) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Western blot analysis of extracts from 3T3 cells treated with EGF using MER/SKY (Phospho-Tyr749/681) Antibody. The lane on the right is treated with the antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human brain tissue using MER/SKY (Phospho-Tyr749/681) antibody (left) or the same antibody preincubated with blocking peptide (right).

Documents

Further Information

Additional Names:
C-mer, MERK, MERTK
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Background References:
  • Graham D.K., Cell Growth Differ. 5:647-657(1994).
  • Gal A., Nat. Genet. 26:270-271(2000).
  • Hillier L.W., Nature 434:724-731(2005).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MER/SKY (phospho Tyr749/681) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 749/681 (K-I-Y (p)-S-G) derived from Human MER/SKY .
Modifications:
Phospho-Specific
NCBI Gene ID #:
10461/7301
NCBI Official Name:
MER proto-oncogene, tyrosine kinase, TYRO3 protein tyrosine kinase
NCBI Official Symbol:
MERTK, TYRO3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
97 kDa
Protein Accession #:
NP_006334.2
Protein GI Number:
66932918
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of MER/SKY only when phosphorylated at tyrosine 749/681.
Swissprot #:
Q12866/Q06418