MAP2K7 (phospho Ser271) Antibody
| Code | Size | Price |
|---|
| PSI-79-855-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
PRKMK7, JNKK2, MKK7, MAP2K7, MP2K7
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
Background References:
- Wu Z., Mol. Cell. Biol. 17:7407-7416(1997).
- Lu X., J. Biol. Chem. 272:24751-24754(1997).
- Foltz I.N., J. Biol. Chem. 273:9344-9351(1998).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MAP2K7 (phospho Ser271) antibody was raised against a peptide sequence around phosphorylation site of Serine271 (V-D-S (p)-K-A) derived from Human MAP2K7.
Modifications:
Phospho-Specific
NCBI Gene ID #:
5609
NCBI Official Name:
mitogen-activated protein kinase kinase 7
NCBI Official Symbol:
MAP2K7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
NP_660186.1
Protein GI Number:
21735544
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of MAP2K7 only when phosphorylated at serine 271.
Swissprot #:
O14733