DDR1 (phospho Tyr513) Antibody
| Code | Size | Price |
|---|
| PSI-79-881-0.1mg | 0.1mg | £488.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
Documents
Further Information
Additional Names:
CAK, RTK6, TRKE, EDDR1
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI).
Background References:
- di Marco E., J. Biol. Chem. 268:24290-24295(1993).
- Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993).
- Laval S., Cell Growth Differ. 5:1173-1183(1994).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DDR1 (phospho Tyr513) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 513 (K-K-Y (p)-V-R) derived from Human DDR1 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
780
NCBI Official Name:
discoidin domain receptor tyrosine kinase 1
NCBI Official Symbol:
DDR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
110 kDa
Protein Accession #:
NP_001189450.1
Protein GI Number:
729008
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of DDR1 only when phosphorylated at tyrosine 513.
Swissprot #:
Q08345