CtBP1 (phospho Ser422) Antibody

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ProSci
Product Code: PSI-79-906
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-906-0.1mg0.1mg£488.00
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Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.

Images

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Western blot analysis of extracts from Jurkat cells treated with TNF using CtBP1 (Phospho-Ser422) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Immunohistochemical analysis of paraffin-embedded human brain tissue, using CtBP1 (Phospho-Ser422) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Western blot analysis of extracts from Jurkat cells treated with TNF using CtBP1 (Phospho-Ser422) Antibody. The lane on the right is treated with the antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human brain tissue, using CtBP1 (Phospho-Ser422) antibody (left) or the same antibody preincubated with blocking peptide (right).

Documents

Further Information

Additional Names:
CTBP, C-terminal binding protein 1, EC 1.1.1
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
Background References:
  • Schaeper U., Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471(1995).
  • Sewalt R.G.A.B., Mol. Cell. Biol. 19:777-787(1999).
  • The MGC Project Team, Genome Res. 14:2121-2127(2004).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CtBP1 (phospho Ser422) antibody was raised against a peptide sequence around phosphorylation site of Serine 422 (A-P-S (p)-P-G) derived from Human CtBP1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
1487
NCBI Official Name:
C-terminal binding protein 1
NCBI Official Symbol:
CTBP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa
Protein Accession #:
NP_001319.1
Protein GI Number:
4557497
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of CtBP1 only when phosphorylated at serine 422.
Swissprot #:
Q13363